South Beach, Miami, Florida

Packed with runway-ready locals, glamorous nightclubs, spectacular warm weather and picture-perfect beaches, there's something inherently sexy about Miami's South Beach. The ultimate getaway for nightlife lovers, the Ocean Drive strip of restaurants and clubs is always a scenester's haven, and there are plenty of swank places to sleep in late after a night on the town. Among the most luxurious is Asian-inspired The Setai. A Zen-like counterbalance to trendier hotels, suites are spacious and serene, the pool areas feature three pools with three different temperatures and the hotel spa offers in-room treatments. When the sun goes down, the hotel's courtyard transforms into a sexy lounge with mood-making ambient music.